abrasive, aggravating, annoying, bothersome, carking, chafing, disturbing, exasperating, frustrating, galling, irksome, irritating, maddening, nettlesome, nettling, peeving, pesky, pestiferous, pestilent, pesty, plaguey(also plaguy), rankling, rebarbative, riling, vexatious, vexing

burdensome, discomforting, displeasing, disquieting, distressing, importunate, importune, inconveniencingangering, enraging, infuriatingbrattish, bratty, mischievous, offensive, troublesome, upsettingdistractive, painful, stressful, tiresome, troubling, trying, worrisomebiting, grating, jangling, jarring, spiny, thorny